Delmar Fire Dept, Sussex County EMS and Delaware State Police Trooper 2 were alerted for a serious Motor Vehicle Collision with entrapment on Old Stage Road south of Iron Hill Road on the Delaware side. Paramedic B-74 arrived on-scene to find a single vehicle that had gone off the roadway, struck a tree then bounced off and spun around 180 degrees. There was significant front end damage to the vehicle. The front passenger was confirmed to be trapped in the vehicle due to dashboard intrusion. Rescue 74 arrived on-scene and placed the hydraulic cutter in service. Paramedic B-74's crew remained inside the vehicle treating the patient while the Rescue crew worked outside removing both doors off the passenger side of the car and removing the B-post. Sussex County EMS Medic units 102 and 202 responded to the scene. Trooper 2 was cancelled and the most seriously injured patient was extricated and transported by ground ambulance to the nearest trauma center. A total of 4 patients were transported to the hospital. Rescue 74 and Engine 74-1 responded from Delmar Fire Dept.